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5. CRP (C-Reactive Protein). One of the key markers to measure whole body inflammation is CRP. Elevated CRP levels have been linked to heart disease, erectile dysfunction and a host of other chronic diseases. One study on type II diabetics using 600 mg/day of Grape Seed Extract decreased hsCRP from 3.2 to 2.0 mg/l, a very significant drop needless to say. 
6. Glutathione. One very impressive result of the study in #4 is that Grape Seed Extract increased glutathione levels by 52%. This is very impressive as glutathione is the master detoxer of the body and this should definitely protect one's long term health.
7. Venous Insufficiency. Grape Seed Extract seems to significantly help with venous insufficiency.  Venous insufficiecy is a disease of poor circulation and should be confused with Venous Leakage, which has a more direct effect on erectile function. Venous insufficiency plagues diabetics, for example, who cannot get proper circulation to their extremities allowing fluid and toxins to build up there.
SUPERCHARGE FOR ERECTILE STRENTH: This has not been proven in any study, but it is likely that adding low dose Arginine or Citrulline daily along with Grape Seed Extract will yield synergies. Citrulline has shown beneftis by itself to lower blood pressure and improve erectile dysfunction as I discuss in my page on The Benefits of Citrulline. Basically, Citrulline can supply a much needed base quantity of nitric oxide, which is important for middle aged men and then Grape Seed Extract can act on eNOS to make sure that that nitric oxide is preserved. Common dosages with Citrulline are 3 X 500 mg or 3 X 1 gram daily.
DOSAGE: Now, before I go on, I do have to say that one of the advantages of Pycnogenol is that they require solid standards with their extracts and seem to have good quality control. There will undoubtedly be more variability in any Grape Seed Extracts purchased. Furthermore, notice that the above studies use a wide range of dosages, 150 mg - 2 grams per day - in order to achieve the desired clinical effect.
LONG TERM SAFETY: It is true that Grape Seed Extract looks very promising to help men with erectile dysfunction, long term safety has not been established. As far as I know, all the studies have just looked at Grape Seed Extract for a few months and that is it.
CAUTIONS: Grape Seed Extact is known to be an aromatase inhibitor, which potentially could raise you testosterone a little . It also, in vitro at least, gives Vitamin C a longer shelf life. However, Grape Seed Extract has a couple of cautions that need to go along with it: 1) in combination with Vitamin C it apparently raises blood pressure  and 2) it may slightly decrease free testosterone because it can raise SHBG, the protein that binds to testosterone.
CAUTION: If you have a medical condition or are on any medications, please discuss any changes with your doctor first. Certain supplements, foods and even juices can alter absorption rates of certain medications for example. Play it safe.
1) Clinical Science, 2008, 114:331–337, "Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract"
2) Metabolism, Dec 2009, 58(12):1743–1746, "Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome"
3) Cell & Molecular Biology, 34(10), "Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium"
4) Diabetic Medicine, May 2009, 26(5):526-531, "Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity"
5) Acta Pharacologica, Dec 2001, 22(12), "Anti-inflammatory effect and mechanism of proanthocyanidins from grape seed"
6) Nitric Oxide, Apr 2001, 5(2):137–149, "Protection of Primary Glial Cells by Grape Seed Proanthocyanidin Extract against Nitrosative/ Oxidative Stress"
7) Journal of Cardiovascular Pharmacology, Oct 2005, 46(4):445-451, "Grape Seed and Skin Extracts Inhibit Platelet Function and Release of Reactive Oxygen Intermediates"
8) Journal of Biomedicine and Biotechnology, 2004, 5:272-278, "Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects"
10) J Hypertensm 2005 Feb, 23(2):427-34, "The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial"
11) Cancer Res. 2006 Jun 1;66(11):5960-7
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